Identification of keratin 19‐positive cancer stem cells associating human hepatocellular carcinoma using CYFRA 21‐1
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منابع مشابه
Identification of keratin 19‐positive cancer stem cells associating human hepatocellular carcinoma using CYFRA 21‐1
The current lack of an easily measurable surrogate marker of cancer stem cells (CSCs) prevents the clinical application of CSCs for hepatocellular carcinoma (HCC). We previously reported that keratin 19 (K19) is a novel HCC-CSC marker associated with transforming growth factor beta (TGFβ)/Smad signaling, and that K19+ HCC-CSCs could be a new therapeutic target of TGFβ receptor 1 inhibitor LY215...
متن کاملBiology of Human Tumors Keratin 19, a Cancer Stem Cell Marker in Human Hepatocellular Carcinoma
Purpose:Keratin 19 (K19) is a knownmarker of poor prognosis and invasion in human hepatocellular carcinoma (HCC). However, the relationship between K19 and cancer stem cells (CSCs) is unclear. Here, we determinedwhether K19 can be used as a new CSC marker and therapeutic target in HCC. Experimental Design: HCC cell lines were transfected with a K19 promoter–driven enhanced green fluorescence pr...
متن کاملKeratin 19, a Cancer Stem Cell Marker in Human Hepatocellular Carcinoma.
PURPOSE Keratin 19 (K19) is a known marker of poor prognosis and invasion in human hepatocellular carcinoma (HCC). However, the relationship between K19 and cancer stem cells (CSCs) is unclear. Here, we determined whether K19 can be used as a new CSC marker and therapeutic target in HCC. EXPERIMENTAL DESIGN HCC cell lines were transfected with a K19 promoter-driven enhanced green fluorescence...
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There is great interest in the biology of liver progenitor cells (LPCs) because of their stem cell-like ability to regenerate the liver when the hepatocyte pool is exhausted. Barely detectable in healthy tissue, they emerge upon chronic insult in periportal regions, proliferate and migrate to injury sites in the parenchyma and eventually differentiate into hepatocytes and cholangiocytes to rest...
متن کاملEmergence of cancer stem cells in hepatocellular carcinoma.
Liver cancer represents the second most deadly human malignancy. The major histological subtype called hepatocellular carcinoma (HCC) arises by chronic inflammation-triggered regenerative responses of normally quiescent hepatocytes and progenitors, respectively. Such regenerative stress accelerates the accumulation of genetic and epigenetic changes (Yamashita & Wang, 2013), while detailed mecha...
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ژورنال
عنوان ژورنال: Cancer Medicine
سال: 2017
ISSN: 2045-7634,2045-7634
DOI: 10.1002/cam4.1211